Title:
神経変性疾患の予防又は治療薬
Document Type and Number:
Japanese Patent JP4469441
Kind Code:
B2
Abstract:
A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3 represents a hydrogen atom or a methyl group; and X represents a C10-C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.
Inventors:
Ban Liu
Gabby Schmid
Florence Key Ring
Celine Girlanda-Jungeth
Philip shabert
Juan-Philip Lefler
Bernadette Lutz-Buschel
Joseph-Louis Gonzalez
Masashi Yamada
Yukie Suma
Gabby Schmid
Florence Key Ring
Celine Girlanda-Jungeth
Philip shabert
Juan-Philip Lefler
Bernadette Lutz-Buschel
Joseph-Louis Gonzalez
Masashi Yamada
Yukie Suma
Application Number:
JP18054699A
Publication Date:
May 26, 2010
Filing Date:
June 25, 1999
Export Citation:
Assignee:
Meiji Dairy Co., Ltd.
International Classes:
A61K31/12; A61K31/00; A61K31/122; A61P25/00; A61P25/28; A61P43/00; C07C45/51; C07C45/59; C07C45/67; C07C49/713
Domestic Patent References:
| JP3766591B2 |
Other References:
TETRAHEDRON,1998年,54,P.7735-7748
CLINICAL NEUROSCIENCE,1998年,16(8),P.926-931
PHARMA MEDICA,1998年,16(2),P.83-88
神経変性疾患調査研究班 1994年度研究報告書,1995年,P.132-134
ANNUAL REVIEW 神経,1995年,1995,P.203-209
CURRENT INSIGHTS IN NEUROLOGICAL SCIENCE,1998年,6(1),P.6
METHODS FIND. EXP. CLIN. PHARMACOL.,1996年,18(SUPPL.B),P.205 P-142
CLINICAL NEUROSCIENCE,1998年,16(8),P.926-931
PHARMA MEDICA,1998年,16(2),P.83-88
神経変性疾患調査研究班 1994年度研究報告書,1995年,P.132-134
ANNUAL REVIEW 神経,1995年,1995,P.203-209
CURRENT INSIGHTS IN NEUROLOGICAL SCIENCE,1998年,6(1),P.6
METHODS FIND. EXP. CLIN. PHARMACOL.,1996年,18(SUPPL.B),P.205 P-142
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba
Sumio Tanai
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba
Sumio Tanai