PROCESS AND INTERMEDIATES TO PREPARE LATANOPROST

Title:

PROCESS AND INTERMEDIATES TO PREPARE LATANOPROST

Document Type and Number:

Japanese Patent JP2007016050

Kind Code:

A

Abstract:

To provide a new process for preparing 15(S)-prostaglandin intermediates.

The process for preparing 15(S)-prostaglandin intermediates compounds (IV) and (XVIII) comprises: a step (1) of contacting the corresponding enone with (-)-chlorodiisopinocampheylborane while maintaining the reaction mixture temperature in the range of from about -50°C to about 0°C; and a step (2) of contacting the reaction mixture of step (1) with a boron complexing agent.

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Inventors:

HENEGAR KEVIN E

Application Number:

JP2006274261A

Publication Date:

January 25, 2007

Filing Date:

October 05, 2006

Export Citation:

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Assignee:

PHARMACIA & UPJOHN CO LLC

International Classes:

C07D307/83; A61K31/5575; C07D307/935; A61P27/02; C07C59/11; C07C59/54; C07C59/72; C07C405/00

Domestic Patent References:

JPH10506893A	1998-07-07
JPH10504307A	1998-04-28
JPH06345777A	1994-12-20

Foreign References:

WO1999016756A1

1999-04-08

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura

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