Title:
ノルモルフィナン塩を調製するためのプロセス
Document Type and Number:
Japanese Patent JP5478506
Kind Code:
B2
Abstract:
The invention provides a process for the conversion of opioid derivatives into normorphinan compounds useful for making “nal” compound analgesics and antagonists. In particular, the process may be used for the production of pure normorphinan salts from crude opioid substrates.
Inventors:
One, Peter X.
Chan, Tao
Cantrell, Gary Elle.
Burber Rich, David W.
Trawick, Bobby N.
Bao, Chang
Chan, Tao
Cantrell, Gary Elle.
Burber Rich, David W.
Trawick, Bobby N.
Bao, Chang
Application Number:
JP2010539461A
Publication Date:
April 23, 2014
Filing Date:
December 17, 2008
Export Citation:
Assignee:
Mallinck Rod LRC
International Classes:
C07D489/08; A61K31/485; A61P25/04
Domestic Patent References:
| JP60258183A | ||||
| JP60252481A |
Foreign References:
| WO2006084412A1 | ||||
| WO2007137782A1 |
Other References:
E GREINER,SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS.18. N-SUBSTITUTED 以下備考,JOURNAL OF MEDICINAL CHEMISTRY,2003年,V46 N9,P1758-1763,14-PHENYLPROPYLOXYMORPHINAN-6-ONES WITH UNANTICIPATED AGONIST PROPERTIES
SCHMIDHAMMER,SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS PART 4 OPIOID AGONISTS 以下備考,HELVETICA CHIMICA ACTA,スイス,VERLAG HELVETICA CHIMICA ACTA,1989年 1月 1日,V72 N6,P1233-1240,AND PARTIAL OPIOID AGONISTS IN A SERIES OF N-(CYCLOBUTYLMETHYL)-14-METHOXYMORPHINAN-6-ONES
NINAN A,AN IMPROVED SYNTHESIS OF NOROXYMORPHONE,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHER,1992年 1月 1日,V48 N32,P6709-6716
SCHMIDHAMMER,SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS PART 4 OPIOID AGONISTS 以下備考,HELVETICA CHIMICA ACTA,スイス,VERLAG HELVETICA CHIMICA ACTA,1989年 1月 1日,V72 N6,P1233-1240,AND PARTIAL OPIOID AGONISTS IN A SERIES OF N-(CYCLOBUTYLMETHYL)-14-METHOXYMORPHINAN-6-ONES
NINAN A,AN IMPROVED SYNTHESIS OF NOROXYMORPHONE,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHER,1992年 1月 1日,V48 N32,P6709-6716
Attorney, Agent or Firm:
Takeshi Oshio