PROCESS FOR SYNTHESIS OF AZETIDINONES

Title:

PROCESS FOR SYNTHESIS OF AZETIDINONES

Document Type and Number:

Japanese Patent JP2012036224

Kind Code:

A

Abstract:

To provide a process for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents.

The process includes reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent. The cyclizing agent is selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride.

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Inventors:

THIRUVETTIPURAM THIRUVENGADAM K
CHIU JOHN S
FU XIAOYONG
MCALLISTER TIMOTHY L

Application Number:

JP2011252865A

Publication Date:

February 23, 2012

Filing Date:

November 18, 2011

Export Citation:

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Assignee:

SCHERING CORP

International Classes:

C07D205/08; C07D201/02

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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