Title:
PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES
Document Type and Number:
Japanese Patent JP2023115354
Kind Code:
A
Abstract:
To provide processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses.SOLUTION: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies. The invention provides inter alia human epigenetic biomarkers that are useful for the noninvasive detection of fetal genetic traits, including, but not limited to, the presence or absence of fetal nucleic acid, the absolute or relative amount of fetal nucleic acid, fetal sex, and fetal chromosomal abnormalities such as aneuploidies.SELECTED DRAWING: None
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Inventors:
MATHIAS EHRICH
ANDERS OLOF HERMAN NYGREN
ANDERS OLOF HERMAN NYGREN
Application Number:
JP2023108402A
Publication Date:
August 18, 2023
Filing Date:
June 30, 2023
Export Citation:
Assignee:
SEQUENOM INC
SEQUENOM CENTER FOR MOLECULAR MEDICINE
SEQUENOM CENTER FOR MOLECULAR MEDICINE
International Classes:
C12N15/10; C12Q1/68; C12Q1/6806; C12Q1/6809; C12Q1/6816; C12Q1/6844; C12Q1/6874
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto