Title:
PROCESSES FOR PREPARATION OF 7-ALPHA-CARBOXYL-9,11-EPOXY STEROID COMPOUND AND INTERMEDIATE USEFUL THEREIN AND GENERAL PROCESS FOR EPOXIDATION OF OLEFINIC DOUBLE BOND
Document Type and Number:
Japanese Patent JP2008100996
Kind Code:
A
Abstract:
To synthesize epoxymexrenone and an epoxymexrenone-based compound.
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone compounds of the formula I, wherein: -A-A- represents the group -CHR4-CHR5- or -CR4=CR5-; R3 is independently selected from proper substituents; R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxycarbonyl group; -B-B- represents the group -CHR6-CHR7- or an alpha- or beta- oriented group; R8 and R9 are each independently selected from proper substituents, or together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
Inventors:
NG JOHN S
WANG PING T
BAEZ JULIO A
LIU CHIN
ANDERSON DENNIS K
LAWSON JON P
ERB DERNHARD
WIECZOREK JOSEPH
MUCCIARIELLO GENNARO
VANZANELLA FORTUNATO
KUNDA SASTRY A
LETENDRE LEO J
POZZO MARK J
SING YUEN-LUNG L
WANG PING T
BAEZ JULIO A
LIU CHIN
ANDERSON DENNIS K
LAWSON JON P
ERB DERNHARD
WIECZOREK JOSEPH
MUCCIARIELLO GENNARO
VANZANELLA FORTUNATO
KUNDA SASTRY A
LETENDRE LEO J
POZZO MARK J
SING YUEN-LUNG L
Application Number:
JP2007265977A
Publication Date:
May 01, 2008
Filing Date:
October 12, 2007
Export Citation:
Assignee:
GD SEARLE LLC
International Classes:
C07J21/00; A61K31/58; C07J19/00; C07J31/00; C07J53/00; C07J71/00; C12P33/00; C12P33/10; C12Q1/02
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda