Title:
PRODUCING CELL STRAIN ENHANCER
Document Type and Number:
Japanese Patent JP2023153268
Kind Code:
A
Abstract:
To provide a method for improving yield of useful multi-subunit protein.SOLUTION: There is provided a producing cell strain of a CHO cell or the like of a standard biological preparation-producing mammalian cell which contains recombinant polynucleotide coding endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 2 (EDEM2). Further, a producing cell contains both polynucleotide which codes EDEM2 and polynucleotide which codes XBP1. The strength of antibody produced by the cell strains is improved, and cell density achieved by the cells during culture is improved.SELECTED DRAWING: None
Inventors:
CHEN GANG
DARYA BURAKOV
DIPALI DESHPANDE
DARYA BURAKOV
DIPALI DESHPANDE
Application Number:
JP2023134346A
Publication Date:
October 17, 2023
Filing Date:
August 22, 2023
Export Citation:
Assignee:
REGENERON PHARMA
International Classes:
C12N15/12; C12N5/10; C12N15/13
Attorney, Agent or Firm:
Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Maki Shioda
Kazuya Kawamoto
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Maki Shioda
Kazuya Kawamoto
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