PRODUCTION OF 2-AMINOBENZYLALCOHOL

Japanese Patent JP3547017

B2

PURPOSE: To obtain 2-amino benzylalcohols of high purity, which are important intermediates as raw materials of drugs, at a high yield by using a simple operation, i.e., hydrogenation of 2-nitro-benzaldehydes in the presence of a metal catalyst.
CONSTITUTION: 2-Aminobenzylalcohols of formula II is obtained by a hydrogenation of 2-nitrobenzaldehydes of formula I (each one of R1 and R2 is H, an alkyl, an alkoxy or a halogen) in the presence of a metal catalyst. As to the metal catalyst, palladium or platinum is preferable. And also nickel, especially Raney nickel is preferable. This reaction is preferably conducted at 10-150°C, specifically at 40-80°C, and at a reacting hydrogen pressure of 2-20kg/cm12 (gage pressure), specifically at 3-20kg/cm2. As to the compound of formula I, e.g. 4,5- dimethoxy-2-nitrobenzaldehyde, 4,6-dimethoxy-2-nitrobenzaldehyde, 3,6- dimethoxy-2-nitrobenzaldehyde, etc., can be used.

Kenji Kunikata

JP5258994A

July 28, 2004

February 28, 1994

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NIPPON KAYAKU KABUSHIKI KAISHA

B01J25/02; C07B61/00; C07C213/00; C07C215/68; (IPC1-7): C07C215/68; C07C213/00

JP62242651A
JP58067637A
JP62033139A

SATO K. et al.,Bull. Chem. Soc. Jpn,1968, Vol.41,p.442-444
Friedlander P. et al.,'424. Zur Reduktion des Orthonitrobenzaldehyds.',Chem. Ber.,1882,p.2105-2110
Hans Plieninger,'Indolderivate, I. Mitteil: Die Synthese der Indol-diessigsauren-(3.4) und -(3.6)',Chem. Ber.,1954, Vol.87, No.2,p.228-231

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