PURPOSE: To obtain the subject compounds that are useful as antileukemic agents by conducting silanization and acylation of chloroadenosine in order, by reacting the obtained product with an organotin hydride and a radical initiator, and then by desilanizing the obtained product.

CONSTITUTION: First, 2-chloroadenosine of formula I is reacted with a silanizing agent (example: 1,3-chloro-1,1,3,3-tetraisopropyldisiloxane) of formula (i-Pr)4Si2O (X)2 (X is Cl or Br) and the obtained new intermediate is acylated with an acylating agent (preferably, phenylchlorothionoformate) of formula XC(S)Z [Z is R2 or YR2 (Y is O or S; R2 is a 1-5C linear alkyl or phenyl)]. Then, the obtained new intermediate of formula II is reacted with an organotin hydride (example: triphenyl tin hydride) and a radical initiator (example: azobis (1- cyanocyclohexane)] to obtain a new intermediate of formula III. Finally, the obtained intermediate is desilanized to obtain the objective compound of formula IV.