Title:
PRODUCTION OF 2-FLUOROCYCLOPROPANECARBOXYLIC ACID COMPOUND
Document Type and Number:
Japanese Patent JP3743867
Kind Code:
B2
Abstract:
PURPOSE: To easily obtain a 2-fluorocyclopropanecarboxylic acid compound in high yield in an industrially advantageous way a simple operation without the need of hydrogen feed, useful as an intermediate for e.g. medicines and agrochemicals, by spreading a Raney nickel alloy in the presence of a specific carboxylic acid compound.
CONSTITUTION: This compound of formula II is obtained by using, in the presence of (A) a 2-halo-2-fluorocyclopropanecarboxylic acid compound of formula I (R is H or a lower alkyl; X is Cl, Br or I) (e.g. 2-chloro-2- fluorocyclopropanecarboxylic acid), (B) 0.1-1wt. time, based on the component A, of a Raney nickel alloy (e.g. containing 40-50wt.% of Ni) followed by spreading the component B. It is preferable that the spreading operation be conducted in the presence of a combination of a lower alkylenediamine with at least one kind of base selected from ammonia and organic bases (esp. ammonia, a lower alkylamine or lower amino alcohol).
Inventors:
Nobushige Itaya
Ryuhei Wakita
Kubo Aiko
Mikio Sasaki
Takashi Namba
Yusuke Yukumoto
Ryuhei Wakita
Kubo Aiko
Mikio Sasaki
Takashi Namba
Yusuke Yukumoto
Application Number:
JP1145296A
Publication Date:
February 08, 2006
Filing Date:
January 26, 1996
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
Daiichi Pharmaceutical Co., Ltd.
Daiichi Pharmaceutical Co., Ltd.
International Classes:
B01J25/02; C07C61/15; C07B61/00; C07C51/377; (IPC1-7): C07C61/15; B01J25/02; C07C51/377; //C07B61/00
Domestic Patent References:
| JP2078644A | ||||
| JP3141235A |
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Takeshi Ohara
Hiroji Nakagawa
Yasumitsu Tate
Kenji Saito
Kakehi Yuro
Takeshi Ohara
Hiroji Nakagawa
Yasumitsu Tate
Kenji Saito