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Title:
PRODUCTION OF 3-PROPIONYLSALICYLIC ACID OR ITS ESTER
Document Type and Number:
Japanese Patent JPS58164544
Kind Code:
A
Abstract:

PURPOSE: A 3-propenylsalicylic acid is converted into a halohydrin, dehydrogenated, reduced and deprotected in its 2-hydroxyl to give the titled compound as an intermediate of drugs inexpensively in high yield.

CONSTITUTION: A 3-propenylsalicylic acid with protected 2-hydroxyl of formulaI (R1 is hydrocarbon radical; R2 is protecting group; X is halogen) such as 2- hydroxy-3-propenylbenzoic acid or its ester is converted into its halohydrin with a halogenating agent such as Br2 to give 3-(α-hydroxy-β-halopropyl) derivative of formula III. The product is reduced with a reducing agent to prepare a compound of formula IV in which the halogen atom is replaced with a hydrogen atom, then the protecting group is removed, or both of reactions are effected simultaneously to give the objective compound of formula V.

USE: A starting material of 3-methylflavon-8-carboxylic acid used as an intermediate of drugs.


Inventors:
HIROWATARI NORIYUKI
Application Number:
JP4562282A
Publication Date:
September 29, 1983
Filing Date:
March 24, 1982
Export Citation:
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Assignee:
MITSUI PETROCHEMICAL IND
International Classes:
C07C67/30; C07C51/00; C07C51/347; C07C65/40; C07C67/00; C07C69/84; C07C69/88; (IPC1-7): C07C51/347; C07C65/40; C07C67/30; C07C69/84
Attorney, Agent or Firm:
Shigemitsu Nakajima



 
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