PURPOSE: To readily obtain a compound useful as a synthetic intermediate tor medicines in high purity and yield in a short time without accompanying side reaction, by reacting a 1,4-dihydroxyindane with a carboxylic acid anhydride in the presence of magnesium chloride.
CONSTITUTION: 1,4-dihydroxyindane and a carboxylic acid anhydride are stirred using magnesium chloride as a catalyst while being heated at 80-120°C for about 3hr to afford the aimed substance. The carboxylic acid anhydride is used in a molar amount of ≥2 times based on the 1,4-dihydroindane and the magnesium chloride is used in an amount of ≥0.1mol%. Problems of a conventional method can be overcome at a stroke by using the readily available and safe magnesium chloride to provide 4- or 7-acyloxyindene which is an intermediate for indenolol hydrochloride and indeloxazine hydrochloride.
TAKAGAKI HIDEJI
YAMAZAKI KEIJI
Next Patent: PRODUCTION OF ALKYL PYRUVATE