PRODUCTION OF 4-FLUOROTHIOPHENOL

Japanese Patent JP3832599

B2

PURPOSE: To provide a method for producing 4-fluorothiophenol, capable of allowing each process to proceed in a good yield and capable of giving the compound in a high purity and in a high yield by allowing 4- fluorobenzenesulfonyl chloride to react with sodium bisulfite, reducing the reaction product with SO2, and finally allowing the reaction product to react with NaBH4 in a specific organic solvent.
CONSTITUTION: This method for producing 4-fluorothiophenol comprises allowing 4-fluorobenzenesulfonyl chloride to react with sodium bisulfite in a solvent, reducing the obtained sodium 4-fluorobenzenesulfinate with sulfur dioxide, allowing the obtained 4,4'-difluorodiphenyl difulfide to react with sodium borohydride in an inactive organic solvent miscible with water, evaporating off e.g. the solvent from the obtained 4-fluorothiophenol sodium salt solution, acidifying the obtained solution, separating an organic phase and, if suitable, purifying the organic phase. The method may be performed as an one pot synthesis. The fluorothiophenol is useful as an intermediate for producing pharmaceutically active substances.

WO/2005/085216	ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT
JP6766556	Liquid crystal compounds, liquid crystal compositions and liquid crystal display devices

Helmut Huige
Ferdeanand Hagedorn
Wolfgang Ayman
Otto Neuner
Herbert Miular

JP16705095A

October 11, 2006

June 09, 1995

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Bayer Aktiengesellschaft

C07C323/09; C07C313/14; C07C319/06; C07C319/24; (IPC1-7): C07C323/09; C07C319/06

JP56007753A
JP64009972A
JP48019302B1
JP6504053A

Heikichi Odashima

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