Title:
PRODUCTION OF 5-SUBSTITUTED 2-CHLOROPYRIDINES
Document Type and Number:
Japanese Patent JP3145822
Kind Code:
B2
Abstract:
PURPOSE: To obtain 5-substituted 2-chloropyridines in a high yield by a simple method, by reacting acetanamide with a chlorinating agent in the presence of N,N-disubstituted dimethylformamide.
CONSTITUTION: The compd. of formula I [R and R1 are each an alkyl or arylalkyl (each of which may be replaced by a halogen)] such as N-benzyl-N-(1- propenyl)-acetamide is reacted with a chlorinating agent such as phosphoryl chloride, oxalyl chloride and phosgene at a temp. of -30 to 150°C, preferrably -10 to 130°C, in the presence of N,N-disubstituted formamide (such as dimethylformamide) and optionally in the presence of a diluent to obtain the compd. of formula II such as 2-chloro-5-methylpyridine.
Inventors:
Reinhard Ranchille
Application Number:
JP35116092A
Publication Date:
March 12, 2001
Filing Date:
December 07, 1992
Export Citation:
Assignee:
Bayer Actien Gezershyaft
International Classes:
C07D213/61; (IPC1-7): C07D213/61
Domestic Patent References:
| JP4330056A | ||||
| JP5112529A | ||||
| JP5125047A | ||||
| JP60260555A | ||||
| JP4230260A | ||||
| JP1213263A | ||||
| JP5988466A |
Attorney, Agent or Firm:
Heikichi Odashima