Title:
PRODUCTION OF 6-HYDROXYINDOLES
Document Type and Number:
Japanese Patent JPS6379873
Kind Code:
A
Abstract:
PURPOSE: To produce the titled compound useful as a synthetic intermediate for indole alkaloid (a medicine), in high yield and selectivity, by subjecting an 1-acylindole to acylation, oxidation, rearrangement and solvolysis.
CONSTITUTION: A 1-acylindole is acylated by general Friedel-Crafts reaction comprising the reaction with a carboxylic acid in the presence of a protonic acid to obtain a 1,6-diacylindole. The product is oxidized and rearranged by general Baeyer-Villiger reaction comprising the reaction with a peracid in the presence of a strong acid or with hydrogen peroxide in the presence of an acid or base. The obtained 6-acyloxy-1-acylindole is hydrolyzed by conventional method to obtain the objective compound.
Inventors:
NAKATSUKA SHINICHI
Application Number:
JP22535386A
Publication Date:
April 09, 1988
Filing Date:
September 24, 1986
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
C07D209/08; C07D209/16; C07D209/18; C07D209/26; C07D471/04; (IPC1-7): C07D209/08; C07D209/16; C07D209/18; C07D209/26; C07D471/04
Attorney, Agent or Firm:
Kitagawa Fuzo