Title:
PRODUCTION OF (6R)-TETRAHYDRO-L-BIOPTERIN HYDROCHLORIDE
Document Type and Number:
Japanese Patent JP2711828
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain tetrahydrobiopterin hydrochloride useful for medicines, etc., in a high asymmetric synthesis degree in a high purity and in a high yield by catalytically reducing erythrobiopterin, etc., in the presence of an amine compound and platinum black as a catalyst in a prescribed alkaline pH region.
SOLUTION: L-Erythrobiopterin or its acyl derivative represented by formula I (R is H, an acyl) is catalytically reduced in the presence of an amine compound and platinum black as a catalyst in water and/or an alcoholic solvent at a pH of 10-13 at a temperature of ≤20°C under a hydrogen gas pressure of ≥20 kg/cm2. When the product has the acyl group, the acyl group is further removed. Thus, (6R)-tetrahydro-L-biopterin hydrochloride of formula II is obtained.
Inventors:
Hideaki Sakai
Kanai Sada
Kanai Sada
Application Number:
JP16421396A
Publication Date:
February 10, 1998
Filing Date:
June 25, 1996
Export Citation:
Assignee:
Shiratori Pharmaceutical Co., Ltd.
Suntory Limited
Suntory Limited
International Classes:
C07D475/04; B01J23/42; C07B61/00; (IPC1-7): C07D475/04; B01J23/42
Other References:
ＢＵＬＬＥＴＩＮ ＯＦ ＴＨＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ ＯＦ ＪＡＰＡＮ，ＶＯＬ．４６，ＮＯ．１，ＰＰ．２７９−２８２（１９７３）
Attorney, Agent or Firm:
Miyuki Ariga (1 person outside)
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