Title:
PRODUCTION OF 7-NITRO-6-DEMETHYL-6-DEOXYTETRACYCLINE
Document Type and Number:
Japanese Patent JPS6429346
Kind Code:
A
Abstract:
PURPOSE: To obtain the titled compound useful as a synthetic intermediate for a tetracycline antibiotic substance in high selectivity, by nitrating 6- demethyl-6-deoxytetracycline in trifluoromethanesulfonic acid.
CONSTITUTION: The objective compound is produced by nitrating 6-demethyl-6- deoxytetracycline in trifluoromethanesulfonic acid with nitric acid or an alkali metal nitrate at -10W+20°C, preferably -5W+10°C. The amount of the trifluoromethanesulfonic acid is 5W100pts.wt., preferably 10W50pts.wt. per 1pt.wt. of 6-demethyl-6-deoxytetracycline and that of nitric acid or alkali metal nitrate is 1.0W1.1mol. per 1mol. of the 6-demethyl-6-deoxytetracycline.
Inventors:
ONO HIROAKI
HASEGAWA RYOICHI
SANO KAZUAKI
SAITO YOSHINORI
HASEGAWA RYOICHI
SANO KAZUAKI
SAITO YOSHINORI
Application Number:
JP18344087A
Publication Date:
January 31, 1989
Filing Date:
July 24, 1987
Export Citation:
Assignee:
NIPPON KAYAKU KK
International Classes:
C07B43/02; C07B31/00; C07C67/00; C07C231/00; C07C231/12; C07C237/26; (IPC1-7): C07B43/02; C07C102/00; C07C103/19
Attorney, Agent or Firm:
Kazuhiko Takeda
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