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Title:
PRODUCTION OF AMINE DERIVATIVE
Document Type and Number:
Japanese Patent JPH11246552
Kind Code:
A
Abstract:

To safely and easily obtain an amine derivative useful as a medicine, a perfume, etc., in a high yield at a low cost by reducing a nitrile derivative under specific conditions.

This method for producing an amine derivative of the formula: R1CH2NH2 comprises reducing (A) a nitrile derivative of the formula: R1CN {R1 is a group of formula I [a group of formula II is a single bond or a double bond; R2 is H, a lower alkyl, a lower alkoxy or a halogen; (n) is 0, 1-3] or the like) with (B) sodium borohydride in the presence of (C) sulfuric acid. Therein, the component A is preferably 1-[1-(4-fluoropphenetyl)pyridin-4-yl]-6- cyanoindoline, etc., and the components B and C are preferably used in amounts of 1.0-5.0 equivalents and 1.0-5.0 equivalents, respectively. The used solvent is preferably ethylene glycol dimethyl ether, etc.


Inventors:
MIYAZAWA MAMORU
CHIBA HIROYUKI
Application Number:
JP30342998A
Publication Date:
September 14, 1999
Filing Date:
October 26, 1998
Export Citation:
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Assignee:
EISAI CO LTD
International Classes:
C07D401/04; C07C209/48; C07C211/27; C07C211/29; C07C213/02; C07C217/48; C07D207/335; (IPC1-7): C07D401/04; C07C209/48; C07C211/27; C07C211/29; C07C213/02; C07C217/48