Title:
PRODUCTION OF ANTIOSTEOPOROTIC AGENT
Document Type and Number:
Japanese Patent JP2000336094
Kind Code:
A
Abstract:
To obtain a new compound useful as an intermediate for producing triethylsilyl ether analogs of CD ring fragment which are raw materials of vitamin D3 analogs expected as being effective for osteoporosis treatment.
This compound is a compound of formula I (R1 is a lower alkyl), for instance, [1aS-(1aα,3aβ,6aα,6bα)]-[octahydro-3a-methyl-2H-indeno[4,5- b]oxiren-4-ylidene]acetic acid ethyl ester. The compound of formula I is obtained, for instance, in the case of the above-illustrated compound, by reacting a compound of formula II with triethylphosphonoacetate in the presence of sodium ethoxide.
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Inventors:
DANIEWSKI ANDRZEJ ROBERT
RADINOV ROUMEN NIKOLAEV
RADINOV ROUMEN NIKOLAEV
Application Number:
JP2000125034A
Publication Date:
December 05, 2000
Filing Date:
April 26, 2000
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C07D303/16; A61K31/593; A61P19/10; C07C401/00; C07D303/40; C07F7/18; (IPC1-7): C07F7/18; A61K31/593; A61P19/10; C07C401/00; C07D303/40
Domestic Patent References:
JPH1045713A | 1998-02-17 |
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)
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