To produce an arylvinylsulfone useful as a drug intermediate by reacting a specific β-haloethylarylsulfonic acid with an alkali metal salt in the presence of an amine.
A β-haloethylarylsulfonic acid of formula I (R1 and R2 are each H, a halogen, a lower alkyl, a lower alkoxy, nitro, etc.; X is a halogen) is reacted with an alkali metal salt [e.g. an alkali metal (hydrogen) carbonate such as potassium carbonate] of not less than 0.8 molar time as much as the amount of the β-haloethylarylsulfonic acid of formula I in terms of the alkali metal in the presence of an amine (e.g. secondary amine and tertiary amine, such as dimethylamine) of 0.005-0.5 molar time as much as the amount of the β-haloethylarylsulfonic acid of formula I at 0-150°C, if necessary, in the presence of a hydrophobic organic solvent, optionally carrying out a crystallizing treatment of the produced compound to separate the objective compound to industrially and advantageously provide the objective compound of formula II in the method for producing arylvinylsulfone.
KURIHARA AKIO
KURIMOTO ISAO
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