PRODUCTION OF AXIALLY ASYMMETRIC COMPOUND ITS SYNTHETIC INTERMEDIATE, TRANSITION METAL COMPLEX HAVING NOVEL AXIAL ASYMMETRIC COMPOUND AS LIGAND, ASYMMETRIC HYDROGENATION CATALYST, AND ASYMMETRIC CARBON - CARBON BOND-FORMING CATALYST

Title:

Document Type and Number:

Japanese Patent JP3771070

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain a novel compound that is constituted with a ligand comprising a specific aminophosphine and a transition metal, for example, rhodium, shows excellent chemical selectivity, enanthioselectivity and catalytic activity and is useful as a catalyst for asymmetric hydrogenation reaction.
SOLUTION: The objective metal complex is constituted with a ligand of an aminophosphine compound represented by the formula (Ar is an aryl which may be substituted with a halogen or the like; R1 and R2 are each H or the like; (n) is 0) and at least one transition metal selected from rhodium, ruthenium, iridium and nickel. The metal complex is prepared by dissolving an aminophosphine oxide of the formula ((n) is 1; R1 and R2 are each a 5-7C cycloalkyl or the like) in an organic solvent, adding a tertiary amine to the solution, and allowing trichlorosilane to react with the aminophosphine oxide to obtain an aminophosphine of the formula [typically (-)-2-amino-2'-diphenylphosphino-1,1'-binaphthyl or the like] and allowing a salt of a metal such as iridium to react with the aminophosphine.

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Inventors:

Kenzo Sumi
Ryoji Noyori
Takao Ikariya

Application Number:

JP36775598A

Publication Date:

April 26, 2006

Filing Date:

December 24, 1998

Export Citation:

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Assignee:

Takasago International Corporation

International Classes:

B01J31/24; C07F9/50; B01J31/18; C07B53/00; C07B61/00; C07C2/74; C07C13/40; C07C29/17; C07C33/025; C07C311/17; C07F9/53; C07F15/00; C07F15/04; B01J23/44; B01J23/46; (IPC1-7): C07F9/50; B01J31/24; C07B53/00; C07C2/74; C07C13/40; C07C29/17; C07C33/025; C07F9/53; C07F15/00; //C07B61/00; C07M7:00

Domestic Patent References:

JP2000191676A
JP2002520328A

Other References:

Journal of Organic Chemistry (1998), 63(22), p.7738-7748

Attorney, Agent or Firm:

Masumi Hosoda

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