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Patent Searching and Data

Document Type and Number:
Japanese Patent JP3040600
Kind Code:

PURPOSE: To obtain a high-purity carbapenem derivative useful for infectious diseases, having excellent antimicrobial properties and stability simply and efficiently by reacting a specific azetidine derivative with a specific organic phosphorus compound.
CONSTITUTION: The compound of formula I [R1 is lower alkyl or (protected) hydroxy lower alkyl; R2 is H or protected carboxyl; R3 is H, lower alkyl, etc.; R4 is H, lower alkyl, (protected) hydroxyl, etc.; R5 is H, lower alkyl, (protected) hydroxyl, halogen, 67 etc.; R6 and R7 are H, lower alkyl, etc.; Z is CH2, O, S, NHCO, etc.; m and n are 0-4] is reacted with a compound of formula II (R8 is alkoxy, aryloxy, dialkylamino) in an aprotic solvent such as benzene at 80-150°C for 3-50 hours to give the objective derivative of formula III.

Youhei Ishida
Takashi Saito
Toshiyuki Nishi
Takeshi Hayano
Application Number:
Publication Date:
May 15, 2000
Filing Date:
June 30, 1992
Export Citation:
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Daiichi Pharmaceutical Co., Ltd.
International Classes:
A61K31/40; A61K31/397; A61K31/401; A61K31/496; A61P31/04; C07D205/08; C07D403/12; C07D477/00; (IPC1-7): C07D477/00; C07D403/12
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)