PRODUCTION OF CYCLOPENTANE DERIVATIVES

Title:

PRODUCTION OF CYCLOPENTANE DERIVATIVES

Document Type and Number:

Japanese Patent JPS52102270

Kind Code:

A

Abstract:

1508170 2-Formylcyclopentaneheptanoic acid derivatives PFIZER Inc 10 Dec 1975 [11 Dec 1974] 29061/77 Divided out of 1508168 Heading C2C The invention comprises 2-formylcyclopentaneheptanoic acid derivatives of the formula wherein R2 and R3 each are C 1-10 alkyl, C 7-9 aralkyl, or 1- or 2-naphthyl or phenyl optionally substituted by Cl, Br, F, C 1-6 alkyl, C 1-6 alkoxy or phenyl and their preparation by oxidizing the corresponding 2-hydroxymethylcyclopentaneheptanoic acid derivatives. Methyl 7 - [2# - hydroxymethyl - 5α - acetoxyla-cyclopentyl]heptanoate is prepared by the hydrogenation of methyl 7-[2#-benzyloxymethyl- 5α - acetoxy - 1α - cyclopentyl] - cis - 5 - heptenoate, resulting from the acetylation of methyl 7 - [2# - benzyloxymethyl - 5α - hydroxy - 1α- cyclopentyl] - cis - 5 - heptenoate, obtained by esterifying 7 - [2# - benzyloxymethyl - 5α- hydroxy - 1α - cyclopentyl] - cis - 5 - heptenoic acid which is made by reacting (4-carboxybutyl)- triphenylphosphonium bromide with 4#-benzyloxymethyl - 3,3a#,4,5,6,6a# - hexahydro - 2H- cyclopenta[b]furan-2-ol.

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Inventors:

MAIKERU ROSU JIYONSON
TOOMASU KEN SHIYATSUFU
JIEEMUSU FUREDERITSUKU ETSUGUR
JIYASUJIITSUTO SHIN BINDORA
HANSU YURUGEN ERUNSUTO HESU

Application Number:

JP2687477A

Publication Date:

August 27, 1977

Filing Date:

March 11, 1977

Export Citation:

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Assignee:

PFIZER

International Classes:

A61K31/19; A61K31/21; A61K31/215; A61K31/335; A61K31/34; A61K31/343; A61K31/35; A61K31/38; A61P43/00; C07C61/06; C07C67/00; C07C69/74; A61K31/185; C07C401/00; C07C405/00; C07D307/93; C07D307/935; C07D309/12; C07D317/48; C07D317/62; C07D333/24; C07D405/12; C07D407/06; C07D409/06; C07D409/14; C07F7/18; C07F9/40; (IPC1-7): A61K31/19; A61K31/215; A61K31/335; A61K31/34; A61K31/35; A61K31/38; C07C61/06; C07C69/74; C07D307/93; C07D317/48; C07D407/06; C07D409/06

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