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Patent Searching and Data


Title:
PRODUCTION OF CYCLOPENTENE DERIVATIVE
Document Type and Number:
Japanese Patent JPH11158120
Kind Code:
A
Abstract:

To obtain a prostaglandin(PG) by a method which allows to enlarge variation in α- and co-chains of PG skeleton i.e., the reaction of a specific methylcyclopentanone derivative with a specific compound, a specific acid anhydride, and so on.

This compound shown by formula III (e.g. 9-acetoxy-11α,15S- dihydroxy-17S) is obtained by the reaction of a methylcyclopentene derivative shown by formula I [R3 and R4 are each H or a protecting group for OH; R5 is a (substituted) alkyl] with a compound shown by formula II [R2 is H or an alkyl; X1 is a halogen or M-Y (M is a divalent metal; Y is a halogen)] in an inert solvent at -70 to 20°C. followed by the reaction with an acid anhydride shown by the formula (R1)2O (R1 is an alkanoyl) or an acid halide shown by the formula R1X2 (X2 is a halogen) at -78 to 40°C.


Inventors:
URUSHIBARA MASAHIRO
MAKINO MAYUMI
MORISAWA YOSHITOMI
Application Number:
JP32657697A
Publication Date:
June 15, 1999
Filing Date:
November 27, 1997
Export Citation:
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Assignee:
ASAHI GLASS CO LTD
International Classes:
C07C67/08; C07B61/00; C07C67/14; C07C67/343; C07C69/757; C07C405/00; C07F7/18; (IPC1-7): C07C69/757; C07C67/08; C07C67/14; C07C67/343; C07F7/18
Attorney, Agent or Firm:
Kenji Izumina (1 outside)