Title:
PRODUCTION OF DIAZOMETHANE DERIVATIVE
Document Type and Number:
Japanese Patent JP3047059
Kind Code:
B2
Abstract:
PURPOSE: To provide a method for industrially and advantageously producing a diazomethane derivative in which the formation of by-products can be suppressed to afford the diazomethane derivative in high purity and yield.
CONSTITUTION: This method for producing a diazomethane derivative expressed by formula II (Ar is an aryl which may have a substituent group) is to oxidize a hydrazone derivative expressed by formula I in the presence of a phase-transfer catalyst (preferably a quaternary ammonium salt) and an inorganic iodine compound (preferably an alkali metallic salt of hydrogen iodide) in a hydrophobic organic solvent in a two-layer system of a mixed aqueous solution of a caustic alkali at 4-14wt.% concentration in the aqueous solution and sodium hypochlorite at 3-10wt.% concentration in the aqueous solution at -30 to +50°C, preferably -20 to +30°C temperature. The phase-transfer catalyst is used in an amount of preferably 0.001-3wt.% based on the raw material hydrazone derivative and the inorganic iodine compound is used in an amount of preferably 0.01-1 equiv. based on the raw material hydrazone derivative. The reactional yield and selectivity are remarkably improved by regulating the respective concentrations of the caustic alkali and sodium hypochlorite in the mixed aqueous solution thereof within the ranges to suppress the formation of azine compounds, etc.
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Inventors:
Michio Sasaoka
Isao Wada
Ichiro Kawahara
Isao Wada
Ichiro Kawahara
Application Number:
JP31849593A
Publication Date:
May 29, 2000
Filing Date:
December 17, 1993
Export Citation:
Assignee:
Otsuka Chemical Co., Ltd.
International Classes:
B01J31/26; C07B61/00; C07C245/14; (IPC1-7): C07C245/14; B01J31/26
Domestic Patent References:
| JP4980002A |
Other References:
Ｊ．Ｃｈｅｍ．Ｓｏｃ．，Ｐｅｒｋｉｎ Ｔｒａｎｓ．１，Ｖｏｌ．２０（１９７５）ｐ．２０３０−２０３３
Attorney, Agent or Firm:
Eiji Saegusa (4 others)