To obtain a fluorine-containing compound useful as a synthetic intermediate for a medicine, a chemical or a functional material, by carrying out the functional replacement reaction of an α-perfluoroalkylated alcohol derivative, which has been regarded to be difficult, in the presence of a specific compound.
A sulfonic acid ester of an α-perfluoroalkylated alcohol of formula I (R1 and R2 are each H, an alkyl, an aromatic group, an aralkyl, an alkenyl or R1 and R2 form a ring with an adjoining carbon atom; Rf is a perfluoroalkyl; R3 is an alkyl, an aromatic group or a halogen) is reacted with a nucleophilic reagent of the formula HY [Y is Q1R4, Q2R5R6 (Q1 is O, S, selenium or tellurium; Q2 is N, P or arsine; R4 to R6 are each H, alkyl, an aromatic group, etc.; R5 and R6 form a ring) in the presence of a basic substance to give a fluorine-containing compound of formula II. NaOH, KF, phenyllithium may be cited as the basic substance. For example, a compound of formula V is obtained from a compound of formula III and a compound of formula IV by using the method.
HAGIWARA TOSHINORI
YAMAMOTO TOSHINORI
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