PURPOSE: To produce the titled compound useful as an intermediate of quinacridone (a red pigment) or raw material of pharmaceuticals and other synthetic chemicals, in high yield and quality, with littled production of by-products, by reacting diketene with chlorine using a rotary thin film reactor.
CONSTITUTION: γ-Chloroacetoacetyl chloride is produced by reacting diketene with chlorine in an inert solvent such as dichloromethane, carbon tetrachloride, etc. preferably at -20W0°C, introducing diketene and chlorine from the top of a rotary thin film reactor composed of a tubular reactor and a rotary blade inserted in the tube, wherein the reaction raw material introduced into the reactor forms a thin film on the wall of the tube by the rotary force of the blade, and the reaction of the raw material proceeds in the course of flowing down spirally along the tube wall. Since the γ-chloroacetoacetyl chloride is unstable, it is preferably converted to a relatively stable ester, amide, anilide, etc. by reacting with alcohol, phenol, amine, aniline, etc.
NUMAMOTO NORIYOSHI
NAKAJIMA KAZUHISA
