PURPOSE: To readily obtain the titled substance which is a synthetic intermediate for physiologically active substances in high yield, by reacting an isopropenyl ether, etc., having a halogen or alkylsulfonyloxy group at the 1,3-positions as a raw material with a quaternary ammonium fluoride.
CONSTITUTION: An isopropyl ether or ester derivative expressed by formula I [R1 is hydrocarbon group, heterocyclic group or a group expressed by formula II (R2 and R3 are alkyl); X is halogen or alkylsulfonyloxy] is reacted with a quaternary ammonium fluoride, e.g. tetra(n-butyl)ammonium fluiride, etc., preferably at a low temperature, e.g. -10W0°C to eliminate HX and afford the aimed compound expressed by formula III. The compound expressed by formula I is readily synthesized from, e.g. a halocarbonic acid ester expressed by formula IV or a sulfonate expressed by formula V.
NAKAHARA YUKO
TANAKA EIICHI
YOSHIOKA HIROSUKE
NIPPON KAYAKU KK