PRODUCTION OF L-ALLICIN ACETAL - MITSUBISHI GAS CHEMICAL CO

Title:

PRODUCTION OF L-ALLICIN ACETAL

Document Type and Number:

Japanese Patent JP2000086605

Kind Code:

A

Abstract:

To produce L-allicin acetal useful as a raw material and a production intermediate for pharmaceuticals with decreased number of steps at a low cost by treating D,L-allicinamide acetal with a microbial cell, or the like, of a specific microorganism.

The objective compound of formula II is produced by treating D,L-allicinamide acetal of formula I [R1 and R2 are each a lower alkyl or together form an alkylene of the formula (CH2)n ((n) is 2-3)] with microbial cells or treated cells of a microorganism having activity to stereoselectively hydrolyze L-allicinamide acetal (e.g. Mycoplana bullata NCIB 9440). Preferably, the unreacted D-allicinamide acetal is racemized by heating in the presence of a strong base and the produced D L-allicinamide acetal is used again as a raw material. The compound of formula I is a new substance.

Inventors:

TANAKA AKINOBU
DOTANI MASAHARU
UCHIYAMA TAKAKO
TAWARA TORAICHI

Application Number:

JP19054199A

Publication Date:

March 28, 2000

Filing Date:

July 05, 1999

Export Citation:

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Assignee:

MITSUBISHI GAS CHEMICAL CO

International Classes:

C12P13/02; C07C231/06; C07C237/06; C12P41/00; (IPC1-7): C07C237/06; C07C231/06; C12P13/02; C12P41/00

Domestic Patent References:

JPS63157990A	1988-06-30
JPH02501531A	1990-05-31
JPS4839416A	1973-06-09

Other References:

JPN6009052877, Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ, 1995, Ｖｏｌ．３, ｐｐ．１２３７−１２４０
JPN6009052880, パイン有機化学　ＩＩ, 1989, 第５版, ｐ．８１５
JPN6009052882, Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ, 1962, Ｖｏｌ．２７, ｐｐ．７９８−８０２

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