Title:
PRODUCTION OF L-RIBOSE
Document Type and Number:
Japanese Patent JP3932609
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain L-ribose useful as an intermediate for nucleic acid-based antiviral medicines, etc., in a high conversion and in a high yield in a state low in the by-production of impurities by epimerizing L-arabinose in the presence of the compound of a metal such as a nickel compound and a diamine compound.
SOLUTION: This method for producing L-ribose comprises epimerizing L-arabinose in the presence of (A) the compound of a metal such as those of cobalt, strontium, calcium or nickel, e.g. nickel chloride hexahydrate preferably in an amount of 1.5-10 moles per mole of the L-arabinose and (B) a diamine compound such as a diamine compound of the formula (R1-R4 are each H, a 1-10C akyl, a 3-10C cycloalkyl, a 6-16C aryl). The L-ribose is preferably produced by adding (C) a multidentate compound such as oxalic acid, anthranilic acid, dimethylglyoxime and oxide and subsequently epimerizing the L-arabinose.
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Inventors:
Shuji Ichikawa
Hiroshi Iwane
Hiroshi Iwane
Application Number:
JP19377497A
Publication Date:
June 20, 2007
Filing Date:
July 18, 1997
Export Citation:
Assignee:
Mitsubishi Chemical Corporation
International Classes:
C07H1/00; C07H3/02; B01J27/128; C07B35/08; C07B55/00; (IPC1-7): C07H3/02; B01J27/128; C07H1/00; //C07B35/08; C07B55/00
Domestic Patent References:
| JP3502454A | ||||
| JP63022595A | ||||
| JP63022596A | ||||
| JP63022597A | ||||
| JP63115893A | ||||
| JP10218891A |
Other References:
Chem. Pharm. Bull.,1980年,Vol.28, No.4,pages 1324-1326
Anal. Chem.,1982年,Vol.54,pages 123-125
Anal. Chem.,1982年,Vol.54,pages 123-125
Attorney, Agent or Firm:
Hasegawa Soji