PRODUCTION METHOD OF α,β-DIAMINO ACID HAVING OPTICALLY ACTIVE ASYMMETRIC TETRASUBSTITUTED CARBON

Title:

PRODUCTION METHOD OF α,β-DIAMINO ACID HAVING OPTICALLY ACTIVE ASYMMETRIC TETRASUBSTITUTED CARBON

Document Type and Number:

Japanese Patent JP2015145344

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide an easy and high enantioselective synthesis method of α,β-diamino acids having an optically active asymmetric tetrasubstituted carbon, or precursors thereof, by a Mannich reaction using an α-isocyanoacetate on ketimines.SOLUTION: An asymmetric catalytic production method of imidazoline as a precursor of α,β--diamino acids having an optically active asymmetric tetrasubstituted carbon is provided, in which an α-isocyanoacetate is made to react on various ketimines represented by chemical formula (30) below in the presence of a metal species, an asymmetric ligand, and a base.

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Inventors:

NAKAMURA SHUICHI
HAYASHI SHINJI
SHIOMI NORIYUKI
IWANAGA YU

Application Number:

JP2014018164A

Publication Date:

August 13, 2015

Filing Date:

February 03, 2014

Export Citation:

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Assignee:

NAGOYA INST TECHNOLOGY

International Classes:

C07D233/28; C07D235/02; C07D405/04; C07D409/04

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