Title:
ジベンゾチアゼピン化合物類の製造法
Document Type and Number:
Japanese Patent JP2009527458
Kind Code:
A
Abstract:
A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2′-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2′-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2′-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2′-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.
Inventors:
Paul Michael Murray
Louis-Manuel Vaz
Debra Aing
Katsumasa Harada
Nishino prosperity
Kiyotaka Yoshii
Louis-Manuel Vaz
Debra Aing
Katsumasa Harada
Nishino prosperity
Kiyotaka Yoshii
Application Number:
JP2008539592A
Publication Date:
July 30, 2009
Filing Date:
February 21, 2007
Export Citation:
Assignee:
AstraZeneca UK Limited
International Classes:
C07D281/16; C07C319/14; C07C319/20; C07C323/62; C07C323/63; C07B61/00
Attorney, Agent or Firm:
Yanagawa Yasuo