Title:
PRODUCTION METHOD OF (R)-2-AMINO-2-ETHYLHEXANOL
Document Type and Number:
Japanese Patent JP2015003861
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To easily and efficiently produce (R)-2-amino-2-ethylhexanol that is useful as a pharmaceutical intermediate without carrying out a complicated operation.SOLUTION: (R)-2-amino-2-ethylhexanol is produced by subjecting a N-benzylidene-2-amino ester derivative to asymmetric alkylation by using an optically active phase transfer catalyst and subsequently subjecting the derivative to removal of benzylidene, reduction and the like. Further the obtained product is made to react with an optically active acid to form a salt to precipitate a solid product. Thus, a solid of the (R)-2-amino-2-ethylhexanol salt is obtained to improve optical purity.
Inventors:
YOSHIDA AYA
HIRAI YOSHINORI
NISHIYAMA AKIRA
HIRAI YOSHINORI
NISHIYAMA AKIRA
Application Number:
JP2011229047A
Publication Date:
January 08, 2015
Filing Date:
October 18, 2011
Export Citation:
Assignee:
KANEKA CORP
International Classes:
C07C213/10; C07B53/00; C07B57/00; C07C59/50; C07C69/76; C07C213/00; C07C215/08
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