Title:
PRODUCTION OF N-GUANIDINOTHIOUREA SALT AND 3-AMINO-5-MERCAPTO-1,2,4-TRIAZOLE
Document Type and Number:
Japanese Patent JP3328082
Kind Code:
B2
Abstract:
PURPOSE: To readily and inexpensively obtain an N-guanidinothiourea salt which is useful as an intermediate for medicines and agrochemicals by carrying out the thermal reaction of hydrazine and cyanamide which are readily available in industry.
CONSTITUTION: (A) Hydrazine and (B) cyanamide are allowed to react with each other in the presence of an acid such as hydrochloric acid or sulfuric acid in a polar solvent such as water, methanol or ethanol, as they are heated, usually at 50°C - under reflux. (C) The aminoguanidine formed is heated together with (D) a thiocyanate salt in the presence of an acid, preferably at 80-120°C to give an N-guanidinothiourea salt. Further, this N-guanidinothiourea salt is heated under alkaline conditions to give this 3-amino-5-mercapto-1,2,4-triazole.
Inventors:
Takehiko Yoshie
Masanori Sasaki
Masahiro Murotani
Kenichi Ishii
Hajime Mura
Hiroshi Shibuchi
Masanori Sasaki
Masahiro Murotani
Kenichi Ishii
Hajime Mura
Hiroshi Shibuchi
Application Number:
JP30886294A
Publication Date:
September 24, 2002
Filing Date:
December 13, 1994
Export Citation:
Assignee:
Nippon Carbide Industry Co., Ltd.
International Classes:
C07C337/06; C07D249/12; C07D249/14; (IPC1-7): C07C337/06; C07D249/14
Domestic Patent References:
| JP641096A | ||||
| JP625192A | ||||
| JP5247004A | ||||
| JP505175B1 |
Attorney, Agent or Firm:
Takashi Ishida (2 outside)
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