PURPOSE: To obtain the titled compound useful as an intermediate raw material for drugs, agricultural chemicals, etc. under mild reaction conditions in high yield, by reacting an N-hydrogenated nitrogen-containing heterocyclic compound with a formaldehyde as raw materials in the presence of a hydrogenating catalyst under pressure of hydrogen.
CONSTITUTION: One or more N-hydrogenated nitrogen-containing heterocyclic compound selected from N-hydrogenated quinolines, e.g., perhydroquinoline, N-hydrogenated isoquinolines and N-hydrogenated pyridines are reacted with formaldehyde or paraformaldehyde in the presence of a hydrogenating catalyst such as platinum system, e.g., ruthenium catalyst, nickel based catalyst, etc. under ≥5kg/cm2 H2 pressure at normal temperature W150°C for 0.5W15hr, and methylated to give an N-methyl compound.
EFFECT: The titled compound can be produced industrially advantageously without causing problems of corrosion of devices, etc., and forming by-products which are not separated with ease.
TAMURA RYUJI
NAKAMURA TAKASHI
WADA HIROSHI
ONISHI KIYOTAKA
SOEDA MAHITO
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