Title:
PRODUCTION OF N-METHYL-N'-NITROGUANIDINE
Document Type and Number:
Japanese Patent JP3927274
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To produce high-quality N-methyl-N'-nitroguanidine usable as an intermediate for a biologically active compound at a low reaction temperature without using an auxiliary in high yield.
SOLUTION: Nitroguanidine of formula I is reacted with an aqueous solution of methylamine to produce N-methyl-N'-nitroguanidine of formula II. The reaction is carried out by using 1-3mol, preferably 1-2mol of methylamine based on 1mol of the compound of formula I. The reaction temperature can be changed in a relatively wide range, generally 10-30°C and preferably a room temperature. In the reaction, water is used as a diluent. For example, an organic solvent/water base using an organic solvent such as a ketone or an alcohol miscible with water can be used. The compound of formula II can be simply separated without carrying out a purification process.
More Like This:
| WO/2001/046129 | METHOD FOR PRODUCING NITROGUANIDINE |
| WO/2003/014076 | BI-DIRECTIONAL SYNTHESIS OF OLIGOGUANIDINE TRANSPORT AGENTS |
Inventors:
Bernd Gallenkamp
Roter Lohe
Roter Lohe
Application Number:
JP8469997A
Publication Date:
June 06, 2007
Filing Date:
March 19, 1997
Export Citation:
Assignee:
Bayer Aktiengesellschaft
International Classes:
C07C277/08; C07C279/36; (IPC1-7): C07C279/36; C07C277/08
Domestic Patent References:
| JP5112521A | ||||
| JP3157308A |
Other References:
KAMIYA S.,Chemical & Pharmaceutical Bulletin,1975年,23(11),p.2744-2748
Attorney, Agent or Firm:
Heikichi Odashima