Title:
PRODUCTION OF N-T-BUTYL-2-PIPERAZINECARBOXAMIDE COMPOUND
Document Type and Number:
Japanese Patent JP3544694
Kind Code:
B2
Abstract:
PURPOSE: To economically obtain in an industrially advantageous way by hydrogenating an N-t-butyl-2-pyrazinecarboxamide compound using, as a catalyst, an inexpensive Raney nickel or Raney cobalt.
CONSTITUTION: Using, as a catalyst, Raney nickel or Raney cobalt, an N-t- butyl-2-pyrazinecarboxamide compound of formula I (R1 and R2 are each H or an alkyl; But denotes tertiary butyl) is hydrogenated (pref. at 70-130°C) to obtain an N-t-butyl-2-piperazinecarboxamide compound of formula II. The compound of the formula I can be prepared by reaction of a cyanopyrazine of formula III with t-butyl alcohol in the presence of sulfuric acid. The compound of the formula II is useful as an intermediate for medicines. By this method, the compound of the formula II can be produced under low pressures easy to handle industrially, in a short reaction time and in high yield.
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Inventors:
Nanao Watanabe
Sadao Asahi
Hideki Kuranishi
Sadao Asahi
Hideki Kuranishi
Application Number:
JP1897494A
Publication Date:
July 21, 2004
Filing Date:
January 18, 1994
Export Citation:
Assignee:
Koei Chemical Industry Co., Ltd.
International Classes:
C07D241/04; B01J25/02; C07B61/00; (IPC1-7): C07D241/04; B01J25/02
Domestic Patent References:
| JP1117869A | ||||
| JP3157373A |
Other References:
西村重夫他、「接触水素化反応-有機合成への応用-」第1版,株式会社東京化学同人,1987年4月10日
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