Title:
PRODUCTION OF NOVEL OXIME DERIVATIVE OF 33CARBAMOYLOXYMETHYLL 77AMINOTHIAZOLYLACETAMIDO CEPHALOSPORANIC ACID AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JPS5325595
Kind Code:
A
Abstract:
The syn isomers of the compounds of formula: , in which R1 represents a saturated or unsaturated C1-C4 alkyl and A represents hydrogen or one equivalent of an alkali metal or alkaline-earth metal or of an amine organic base, are prepared from the syn isomers of the corresponding compounds in which the amino group of the thiazolyl radical is substituted by a group which can be removed by acid hydrolysis or by hydrogenolysis, or by a chloroacetyl group; in the first case, an acid hydrolysis or a hydrogenolysis is carried out, in the second case treatment is carried out with thiourea. The compounds obtained have antibacterial properties; they can be used in the treatment of infectious diseases, especially of staphylococcias and of colibacilloses.
Inventors:
MISHIERU BINIYO
ANDORE RIYUTSU
ANDORE RIYUTSU
Application Number:
JP10007077A
Publication Date:
March 09, 1978
Filing Date:
August 20, 1977
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D501/04; C07D277/20; C07D501/34; (IPC1-7): A61K31/545; C07D501/34; C12D9/04