Title:
PRODUCTION OF OPTICALLY ACTIVE 4-METHYL-2-OXETANONE
Document Type and Number:
Japanese Patent JP3310056
Kind Code:
B2
Abstract:
PURPOSE: To easily obtain the subject compound in high optical purity at a low cost by the asymmetric hydrogenation of 4-methylene-2-oxetanone in the presence of a ruthenium-optically active phosphine complex as a catalyst.
CONSTITUTION: The objective compound is produced by reacting easily available 4-methylene-2-oxetanone in a solvent (e.g. methylene chloride) at room temperature to 100°C under hydrogen pressure of 5-150kg/cm2 using a ruthenium-optically active phosphine complex as a catalyst and preferably adding a tertiary amine (e.g. diisopropylethylamine) to the reaction system. The ruthenium-optically active phosphine complex used as a catalyst is preferably prepared by using metallic ruthenium and an optically active phosphine at a molar ratio of 1:(1-0.95). The objective compound is useful as a raw material for polymer, synthetic raw material for pharmaceuticals and intermediate used in organic synthetic chemical industries, e.g. intermediate for liquid crystal material.
Inventors:
Takamasa Hidemasa
Tetsuo Ohta
Hidenori Unbayashi
Tetsuo Ohta
Hidenori Unbayashi
Application Number:
JP18349093A
Publication Date:
July 29, 2002
Filing Date:
June 30, 1993
Export Citation:
Assignee:
Takasago International Corporation
International Classes:
C07B53/00; C07B61/00; C07D305/12; C07D315/00; C07F15/00; B01J31/24; (IPC1-7): C07D305/12; B01J31/24; C07B53/00
Domestic Patent References:
| JP61191679A | ||||
| JP3204870A |
Other References:
Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，Ｖｏｌ．２３，ｐ．１７２５−１７２６（１９９２）
Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔ．，Ｖｏｌ．３３，Ｎｏ．５，ｐ．６３５−６３８（１９９２）
Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔ．，Ｖｏｌ．３３，Ｎｏ．５，ｐ．６３５−６３８（１９９２）
Attorney, Agent or Firm:
Nobuo Ono (1 outside)
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