PRODUCTION OF OPTICALLY ACTIVE COMPOUND

Japanese Patent JP3899147

B2

PROBLEM TO BE SOLVED: To provide a method for producing an optically active compound by which the optically active compound used as a raw material for an oxazolidinedione derivative useful as a treating agent for diabetes is produced in a high yield and high purity by performing a reduction reaction of a specific aromatic compound in the presence of a specified ruthenium compound.
SOLUTION: The objective optically active compound of formula III is obtained by performing a reduction reaction of (A) a compound of formula I [R is a (substituted) hydrocarbon group or a (substituted) heterocyclic group; Y is CO, CH(OH), etc.; R1 and R4 are each H or a 1-4C alkyl; A is a divalent 1-7C aliphatic hydrocarbon group; ring E is a benzene ring (substituted by one or two substituting groups); (m) is 0 or 1; (n) is 0-2] in the presence of (B) a compound of formula II [W is an optically active tertiary phosphine; M is Zn, Al, Ti or Sn; X is N(C2H5)3 (B1), CH3CO2 (B2), etc., with the proviso that, when X is B1, (1) is 2 and (h) is 1, when M is Zn, (k) is 4, when M is Al, (k) is 5, when M is Ti or Sn, (k) is 6, etc.], for example, under 30-110kg/cm2 hydrogen pressure at 5-120°C in an organic solvent.

Kawada Mitsuru
Hiroyuki Kouji
Shigeru Mitsuhashi
Takashi Miura
Yukinori Hidenori

JP28218696A

March 28, 2007

October 24, 1996

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Takeda GmbH
Takasago International Corporation

C07D413/04; B01J31/24; C07B53/00; C07B61/00; C07C51/367; C07C59/58; C07C59/90; C07C67/31; C07C69/734; C07C217/18; (IPC1-7): C07C59/58; B01J31/24; C07C51/367; C07C59/90; C07C67/31; C07C69/734; C07C217/18; C07D413/04; //C07B53/00; C07B61/00; C07M7:00

JP7101945A

Takashima Ichi
Shuichi Takahashi
Tsutomu Uchiyama
Tadao Asahina
Hiroshi Mukai

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