Title:
PRODUCTION OF OPTICALLY ACTIVE CYCLOHEXANOLS
Document Type and Number:
Japanese Patent JP3251828
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject compound useful for a synthetic intermediate of pharmaceutical and synthesis of an optically active ligand, etc.
SOLUTION: The objective compound of formula II is produced by carrying out the reaction of 2-substituted cyclohexanone (A) of formula I [R1 is a 1-4C alkyl or (protected) OH] with hydrogen in the presence of an asymmetric hydrogenation catalyst (B) comprising (i) a transition metal compound such as a group VIII transition metal complex of the formula M1XmLn (M1 is Ru, Rh, Ir or Pt; X is H, a halogen or carboxyl, etc.; L is an optically active phosphine ligand; m and n are each an integer), (ii) a basic compound (quaternary ammonium salt) of the formula M2Y [M2 is an alkali (alkaline earth) metal; Y is OH, an alkoxy or a mercapto] and (iii) a nitrogen compound such as an amine.
Inventors:
Toshiyuki Murayama
Takashi Matsumoto
Takashi Miura
Takashi Matsumoto
Takashi Miura
Application Number:
JP28915195A
Publication Date:
January 28, 2002
Filing Date:
October 12, 1995
Export Citation:
Assignee:
Takasago International Corporation
International Classes:
C07B61/00; C07C29/145; C07C35/08; C07C41/26; C07C43/196; B01J31/22; (IPC1-7): C07C35/08; B01J31/22; C07C29/145; C07C41/26; C07C43/196
Domestic Patent References:
| JP8225467A | ||||
| JP8225466A | ||||
| JP5170780A | ||||
| JP5111639A | ||||
| JP63316744A | ||||
| JP63316742A | ||||
| JP60243093A | ||||
| JP50137923A |
Attorney, Agent or Firm:
Hiroshi Nakamoto (1 outside)