Title:
PRODUCTION OF OPTICALLY ACTIVE ERYTHRO-3-AMINO-1,2-EPOXY FORM
Document Type and Number:
Japanese Patent JP3032442
Kind Code:
B2
Abstract:
PURPOSE: To selectively obtain in high yield an optically active erythro-3- amino-1,2-epoxy form with desired configuration by reducing an optically active threo-amino-2-substituted butyric ester derivative and by epoxidizing the product.
CONSTITUTION: This compound of formula III can be obtained by reducing an optically active threo-3-amino-2-substituted butyric ester derivative of formula I (R1 is a 3-12C hydrocarbon; R2 is a (protected) amino; R3 is a 1-12C hydrocarbon residue; R4 is an ester residue; when the configuration of *3 is S- configuration, that of *2 is R-configuration, when the configuration of *3 is R-configuration, that of *2 is S-configuration) followed by epoxidizing the resultant optically active threo-3-amino-2-substituted-1-butanol derivative of formula II in the presence of a base.
Inventors:
Taichi Koshigoe
Hitoshi Sato
Kenichi Yamamoto
Hitoshi Sato
Kenichi Yamamoto
Application Number:
JP31233894A
Publication Date:
April 17, 2000
Filing Date:
November 24, 1994
Export Citation:
Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA
International Classes:
C07D301/02; C07B53/00; C07C309/65; C07C309/73; C07D303/36; (IPC1-7): C07D301/02; C07B53/00; C07C309/65; C07C309/73; C07D303/36
Domestic Patent References:
| JP7508041A | ||||
| JP6502860A |