PURPOSE: To obtain an optically active compound, capable of manifesting lowering actions on cholesterol and triglycerides and useful as a therapeutic agent, etc., for hyperlipemia by carrying out the enzymic asymmetric hydrolyzing reaction of a specific racemic benzoxazepinecarboxylic acid ester, etc.
CONSTITUTION: The enzymic asymmetric hydrolyzing reaction of a compound represented by the formula [R1 is H or a (substituted)hydrocarbon; R2 and R3 are each H, a (substituted)hydrocarbon or a (substituted)aromatic heterocyclic group; X' is a substituent group having an esterified carboxyl group or an acylated hydroxyl group; ring A is a (substituted)benzene ring or a (substituted) aromatic heterocyclic ring; ring J' is a 7- or an 8-membered heterocyclic ring containing ≤3 hetero-atoms as ring constituent atoms and may have a substituent group other than R1 to R3 and X'; C* is asymmetric carbon atom] is carried out to provide the objective optically active compound, having lowering actions on cholesterol and triglycerides and useful as a therapeutic agent, etc., for hyperlipemia.
TARUI NAOKI
IZAWA MIKIO
NAGANO YOICHI
