PRODUCTION OF P-N-SUBSTITUTED AMINOBENZALDEHYDE

Japanese Patent JP3871448

B2

PROBLEM TO BE SOLVED: To obtain a p-N-substituted aminobenzaldehyde in a high yield by reacting a Vilsmeier complex with an N-substituted aniline in an organic solvent, hydrolyzing the reaction product and subsequently extracting off an o-substituted isomer with an acidic aqueous solution.
SOLUTION: This method for producing a p-N-substituted aminobenzaldehyde comprises reacting (B) a Vilsmeier complex [a complex obtained by reacting (i) a secondary acid amide (for example, dimethylformamide) with (ii) a halogenating reagent (for example, phosgene)] with (C) an N-substituted aniline (for example, N,N-dimethylaniline) in (A) an organic solvent (for example, 1,2-dichloroethane) preferably at 0-100°C, hydrolyzing the reaction product, and subsequently extracting off an o-position isomer with an acidic aqueous solution (for example, hydrochloric acid, sulfuric acid or methane sulfonic acid) from the hydrolysate. In the component B, the component(ii)is preferably used in an amount equivalent to the component (i) or in a larger amount than that of the component (i). The component C is preferably used in an amount of 2 to 10 fold moles that of the component (i). The component D is also preferably used in an amount of 0.1-3.0 fold weight that of the component A.

Yusei Nishimura
Fuminobu Takeda
Masaru Wada
Yoshinobu Kanamura

JP27880198A

January 24, 2007

September 30, 1998

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Mitsui Chemicals, Inc.

C07C221/00; C07C223/06; (IPC1-7): C07C223/06; C07C221/00

JP10017520A
JP52125138A
JP56133220A

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