Title:
PRODUCTION OF PIPERIDINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3732005
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate for pharmaceuticals such as paroxetine for antianxiety agent, etc., on an industrial scale in high efficiency by the use of only a small amount of catalyst by introducing a specific glutaric acid alkyl ester into a hydrogen gas atmosphere containing a reduction catalyst.
SOLUTION: The objective compound of formula II [e.g. (±)-cis,trans-4-(4- fluorophenyl)-5-methoxycarbonylpiperidin-2-one] can be produced by introducing (A) a glutaric acid alkyl ester of formula I (R1 and R2 are each a 1-5C alkyl) [e.g. 2-cyano-3-(4-fluorophenyl)glutaric acid dimethyl ester] into a hydrogen gas atmosphere containing (B) a reduction catalyst (e.g. Raney cobalt) preferably under a pressure of atmospheric pressure to about 20 kgf/cm2 at 30-120°C. The components A and B are preferably included or dissolved beforehand in an organic solvent such as methanol.
Inventors:
Kiyoshi Sugi
Shigeya Yamazaki
Taro Ishibashi
Yoshihiro Kawada
Shigeya Yamazaki
Taro Ishibashi
Yoshihiro Kawada
Application Number:
JP9208698A
Publication Date:
January 05, 2006
Filing Date:
April 03, 1998
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
International Classes:
C07D211/78; B01J25/00; C07B61/00; (IPC1-7): C07D211/78; B01J25/00; //C07B61/00
Domestic Patent References:
| JP9278754A | ||||
| JP5025098A | ||||
| JP5032592A | ||||
| JP7215920A | ||||
| JP9157231A | ||||
| JP10081650A |
Attorney, Agent or Firm:
Yoshinori Hosoda
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