Title:
ポリオールからのポリヒドロキシルアルカノエートの生成
Document Type and Number:
Japanese Patent JP4860094
Kind Code:
B2
Abstract:
Recombinant processes are provided whereby additional genes are introduced into E. coli which have been genetically engineered to produce PHA so that the improved strains produce PHA homopolymers and copolymers directly from diols. In preferred embodiments, PHAs containing 4-hydroxybutyrate monomers are produced directly from 1,4-butanediol; PHAs containing 5-hydroxyvalerate are produced from 1,5-pentanediol; PHAs containing 6-hydroxyhexanoate (6HH) are produced from 1,6-hexanediol; PHAs containing 3-hydroxypropionate are produced from 1,3-propanediol; PHAs containing 2-hydroxypropionate (lactate) are produced from 1,2-propanediol (propylene glycol); PHAs containing 2-hydroxyethanoate (glycolate) are produced from 1,2-ethanediol (ethylene glycol). Genes encoding these same enzyme activities can be introduced or their expression amplified in wild type PHA producers to improve the production of PHA homopolymers and copolymers directly from diol and other alcohol feedstocks. The PHA polymers are readily recovered and industrially useful as polymers or as starting materials for a range of chemical intermediates.
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Inventors:
Scarley, Frank A.
Shawl, martha
Shawl, martha
Application Number:
JP2002513911A
Publication Date:
January 25, 2012
Filing Date:
July 20, 2001
Export Citation:
Assignee:
Metabolics, Incorporated
International Classes:
C12N15/09; C12N1/21; C12N15/52; C12N15/53; C12P7/62; C12R1/19
Foreign References:
| WO1999061624A2 | 1999-12-02 | |||
| WO2000008198A1 | 2000-02-17 | |||
| WO2000011188A1 | 2000-03-02 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura