To highly suppress side reactions, improve the yield and produce the subject compound by carrying out a reaction by the coexistence of a base and a substance having dehydrating actions.

(A) A carbonyl compound represented by formula I [A is CHO or COR (R is an alkyl, an aryl, etc.); B is an electron attractive group; X is a halogen] is reacted with (B) an amidino compound represented by formula II (D is an alkyl, an aryl or an aralkyl) in the coexistence of (C) a base, preferably a carbonate such as K2CO3 or Na2CO3 and (D) a substance having dehydrating actions (e.g. a molecular sieve) to produce the objective compound represented by formula III [e.g. 6-cyano-2-(4-ethylphenyl)quinazoline].