To efficiently produce a sesame lignan, having various physiological activities such as lowering actions on cholesterol and preventing actions on drunken sickness, useful as a healthy food, etc., and having high safety at a high concentration by carrying out the direct molecular distillation of a sesame oil.

Various sesame oils such as roasted oil, roasted and refined oil and raw pressed and refined oil are used as a raw material sesame oil and the direct molecular distillation thereof is carried out by using a falling film type molecular distilling machine at 150-270°C temperature at ≤0.1Torr vacuum degree to thereby efficiently afford the objective sesame lignan, having >3wt.% sesamin content, various physiological activities such as lowering actions on cholesterol and preventing actions on drunken sickness, capable of greatly expecting usefulness as a healthy food, etc., and used by crystallization and tableting with a suitable excipient, carrier or additive or formation into a granule and formulating in confectioneries, bread, sprinklings, paste products or edible oils, dressings, mayonnaise, etc.