PURPOSE: To obtain the titled pharmaceutical useful as cholinergic blockers by a method for mass production without decomposition by moisture, heat, etc., by granulating and drying an aqueous solution of pipethanate hydrochloride containing both aluminum silicate and starch hydrolyzate.
CONSTITUTION: An aqueous solution of pipethanate hydrochloride is incorporated with aluminum silicate in an amount of preferably 5W50pts. based on one pt. pipethanate hydrochloride, aluminum silicate powder and starch hydrolyzate in an amount of preferably 1W5pts., based on 1pt. pipethanate hydrochloride, and the resultant mixture is granulated and dried. The concentration of the aqueous solution of the pipethanate hydrochloride is 1W5W/V%, but is preferably 1W3% for granulating and then drying, and 2W5% for the simultaneous granulating and drying. The drying temperature in wet granulating and drying is preferably 50W 60°C for the mixture to be formulated into the pharmaceutical. The starch hydrolyzate is preferably obtained by hydrolyzing starch with an enzyme and has glucose residues in the basic skeleton and further 2W20DE (dextrose equivalent) value.
| JPS5935386 | [Title of the Invention] 2-(omega-amino alkoxy) diphenyl ether |
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| WO/1995/011238 | HETEROCYCLIC AMINES FOR TREATING ISCHAEMIC STROKES |
OKUDA MINORU
OKUMURA FUMIO
