PURPOSE: To profitably obtain the subject compound having a 5α-reductase- inhibiting action by a simple operation comprising reacting a specific carboxylic acid compound with a specified amine compound in the presence of a sulfonyl compound.
CONSTITUTION: A carboxylic acid compound of formula I [A is group of formula II or III (R3 is H, lower alkyl; R4 is H, protected OH, substituted OH, protected carboxy, cyano; the dotted line is single bond or double bond), etc.,] s reacted with an amino compound of formula: NHR R [R,R are H, (substututed) lower alkyl, alkenyl, cycloalkyl] in the presence of a sulfonyl compound such a up mula: R'S0.X (R' is lover alkyl, halogenoalkyl, camphanyl, etc.; X is halogen) to produce the objective compound of formula TV.
KURATA TOMOJI
ISHIBASHI KIMIKI
Next Patent: CASH PROCESSING SYSTEM